Scientists at the University of California, Davis, recently revealed a revolutionary method for treating age-related macular degeneration (AMD) using 3D bioprinting. The team developed an outer blood-retina barrier (OBRB) model by mixing cells and a novel hydrogel before printing the mixture onto a scaffold. The resulting tissue exhibited similar characteristics to a native OBRB, with the ability to take on patterns of drusen deposits and progress to late dry-stage AMD when under induced stress. The researchers are now using their bioprinted OBRB models to continue studying AMD and experimenting with adding other cell types to create more lifelike tissues.
The process began with creating prototype biodegradable scaffolds onto which the mixture of cells and hydrogel was printed. Within days, implanted cells had begun to mature into a dense capillary network. After seeding retinal pigment epithelial cells on the flip side of the scaffold nine days later, they found that tissues had reached “full maturity” by day 42. Subsequent tissue analyses, genetic testing, and functional testing showed that the created tissue exhibited similar characteristics to a natural OBRB. When under induced stress, it even took on patterns of drusen deposits underneath the RPE layer and progressed to late dry-stage AMD – something that was suppressed when Anti-VEGF drugs were administered, restoring tissue morphology.
The findings from this study are expected to open up new possibilities for treating AMD through 3D bioprinting techniques. However, scientists still face several challenges in perfecting these methods and making them suitable for clinical use. Nevertheless, conventional 3D printing has already proven its value in other optical medical procedures, such as repairing eye socket fractures with augmented reality glasses or even creating prosthetic eyes for those whose vision could not be saved medically. With further research into this field likely set to uncover new treatments and technologies in future years, 3D printing looks poised to make an increasingly important contribution toward improving eye health outcomes worldwide.
An in-depth exploration into the effects of advanced macular degeneration has been expounded upon within a new study titled “Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration,” where researchers explored and presented their fascinating findings.
By Leveraging the Power of Health and Wellness, Michelle Jones has Become a Beacon of Hope for Numerous families in her Local Community
Deborah Jones was always passionate about sports and fitness, but it took years to attain a fitness-training certification. After four long months of traveling to Spanish Town every Saturday morning, Deborah finally earned her certification in Sports Education. She returned to the industry with more confidence than ever before.
It wasn’t long before she started getting requests for help from women who wanted to take their health into their own hands. Deborah’s dedication began to inspire these women, and they saw her as a role model and accountability partner on their path toward reaching their goals. With an increasing clientele, Deborah knew she had to expand with more equipment to offer better services; thus, in December 2022, her dream of creating a successful business became a reality.
At present, Deborah focuses primarily on female clients and generational-health practices. She creates a safe space where everyone is accepted regardless of their background or status quo. For many ladies who come to her gym for support, burdens are lifted without having to share any personal details. In her opinion, in this way, confidence can be gained, insecurities can be worked on, and feelings of overall well-being can be developed.
In addition to providing weight loss programs, strength training classes, endurance training sessions, crossfit courses, functional training regimens, and boot camp services, Deborah also emphasizes teaching people within households how important it is to adopt healthy lifestyles. Research shows that even small increases in cholesterol can greatly increase one’s risk of having a heart attack. Therefore, meal planning and prepping have become a team effort at Deborah’s gym as sisters, mothers, and daughters couples work out together while learning the importance of being physically active. Working out together helps one stay committed and builds balance and accountability among family members while promoting fun activities that bring everyone closer together.
Looking ahead into the future, Deborah seeks satisfaction for women and male clients by incorporating more services, such as physiotherapy for those suffering from physical challenges and pre-and postnatal wellness services for mothers, as well as expanding her merchandise line for those who want something extra special from her brand. Furthermore, she is determined to build a stronger clientele base with a reliable, supportive team behind her. To sum up, Deborah’s main goal is to help people become better versions of themselves physically, mentally, emotionally & spiritually.
Struggling to Shed those Extra Pounds? A Recent Study Reveals that Reducing Caloric Intake may be more Effective as Compared to Intermittent Fasting
Recent research indicates that some individuals can reach their desired weight without limiting their eating time.
A recent study discovered that those who ate more frequent large or medium meals were substantially prone to putting on extra pounds.
Experts suggest several small meals throughout the day may help individuals dodge unwanted weight gain.
According to experts, eating healthy and getting the right nutrition is important to maintaining a healthy weight. Nutrition includes protein, fiber, healthy fats, vitamins, and minerals, all of which are necessary to maintain good health.
For many people, it can be difficult to get enough nutrition in their diet. As such, registered dietician Stephanie Rapozo advises her clients to eat three times a day. She stresses that it does not have to necessarily be a full meal; snacks can also contribute to daily nutrition needs as long as they are balanced with the right nutrients.
In a recent study at Harvard University, researchers examined the relationship between meal frequency and size and weight change. The study found that there was indeed a link between the two factors; however, this was only an observational study and therefore did not prove direct cause-and-effect relationships. Additionally, participants had to estimate the size of their meals which could be difficult for some, given how subjective it is.
William Dietz Jr., an obesity researcher and professor of global health at George Washington University, noted this difficulty regarding conducting studies on meal timing and size due to individual differences in how people respond to different approaches, such as intermittent fasting or eating within an 11-hour window (which has been associated with weight loss according to two small pilot studies). In contrast, one larger randomized controlled trial found that fasting for 16 hours each day had no more noticeable impact on weight loss than simply eating regularly throughout the day.
Registered dietician Rapozo has seen success with some clients who have adopted shorter eating windows, such as 11-12 hours per day by stopping eating several hours before bedtime; however, she cautions that those who lose weight by doing so often end up consuming fewer calories overall anyway – so it may not necessarily be attributed specifically to the shorter time frame itself.
Ali suggests utilizing portion guides as well – something like a printable plate template – which can help individuals become more mindful about what they’re eating and how much they’re consuming in terms of quantity and calories.
It should be emphasized, though, that when trying to meet health goals, extreme measures should be avoided since they can lead to disordered eating patterns, especially among people who are more at risk due to having certain biological or temperamental factors such as genetics or increased depression or anxiety levels. Nutritionist Allison Chase recommends seeking professional support instead, which takes into account each person’s circumstances, including their physical and mental health state; additionally, engaging in healthy activities like mindfulness or social interaction can help without needing to rely on unhealthy strategies for reaching goals.
J&J’s Hiv Vaccine Program has been Discontinued due to Unsuccessful Results from its Phase 3 Trial
Pharmaceutical giant Johnson & Johnson has announced that it is ending its phase 3 clinical trial of an HIV vaccine, known as Mosaico after the shot failed to perform better than the placebo. This marks a major setback in the decades-long search for a vaccine that could prevent one of the world’s most devastating diseases.
In a statement released Wednesday, Penny Heaton, Janssen’s global vaccine lead, expressed disappointment at the news but vowed that the company would keep working to find an effective HIV vaccine. She said that the data gathered by Mosaico might help in future efforts.
The trial was launched in 2019 and sought to recruit nearly 4,000 people – primarily gay and bisexual men and transgender individuals – at risk of being infected with HIV. According to Centers for Disease Control (CDC) data from 2016, these populations made up more than half of all cases of HIV infection worldwide and accounted for most new diagnoses. Even more concerningly, research from 2010 showed transgender women were almost 49 times more likely than other adults their age to contract HIV. It is a setback for Janssen and those worldwide who have been fighting to end HIV/AIDS.
Mosaico involved four doses of Johnson & Johnson’s adenovirus vector vaccine over a year and soluble protein injections on visits three and four. The study was conducted through a partnership between Johnson & Johnson, the National Institutes of Health (NIH), and the United States Army Medical Research and Development Command (USAMRDC).
Mosaico’s failure follows another trial known as Imbokodo, which also tested an HIV vaccine developed by J&J but ultimately found it was only 25% effective; even then, results were just outside confidence intervals indicating there may not have been any benefit at all.
The news adds yet another setback in vaccine development for J&J, which recently saw its single-dose COVID-19 vaccine become largely obsolete after two shots administered separately proved much more effective against COVID-19 infection rates than its product. Likewise, Moderna Inc. too has surpassed J&J in the development of an RSV (respiratory syncytial virus) vaccine candidate as part of their collaborative effort with Merck & Co., Inc., having submitted the first applications for regulatory approval last month, whereas J&J trails behind with no timelines given on when their own RSV candidate might be ready for authorization or distribution yet.
Overall this marks another disappointing result in the global fight against HIV/AIDS, which has been ongoing since the 1980s when AIDS first surfaced in America without much knowledge about what caused it or how best to prevent it from spreading further. While we still lack an approved vaccine to protect us against this deadly virus today, researchers remain hopeful that one-day science will provide such protection so that no one will ever have to suffer unnecessarily from AIDS again.